منابع مشابه
Visualization of CD4/CD8 T Cell Commitment
A system to innocuously visualize T cell lineage commitment is described. Using a "knock-in" approach, we have generated mice expressing a beta-galactosidase reporter in place of CD4; expression of beta-galactosidase in these animals appears to be an accurate and early indicator of CD4 gene transcription. We have exploited this knock-in line to trace CD4/CD8 lineage commitment in the thymus, av...
متن کاملT-Cell Development: T-cell lineage commitment revisited
Years of controversy about the lineage relationship between alpha beta and gamma delta T cells may at last have been resolved: it now appears that most T cells derive from an identical T-lineage committed precursor.
متن کاملT cell lineage commitment: identity and renunciation.
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterward. This process involves three levels of regulatory change, in which the cells' intrinsic transcriptional regulatory factors, expression of signaling receptors (e.g., Notch1), and expression of distinct homi...
متن کاملT cell lineage commitment: identity and renunciation1
Precursors undertaking T-cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterwards. This process involves three levels of regulatory change, in which the cells’ intrinsic transcriptional regulatory factors, expression of signaling receptors like Notch1, and expression of distinct homing...
متن کاملT-cell differentiation: Commitment factors for T helper cells
The immune system is designed to eradicate a large variety of invading pathogens with minimum immunopathology. T helper cells, also known as CD4+ T cells, may be subdivided into the T helper 1 (Th1) and the T helper 2 (Th2) subsets, which produce distinct profiles of cytokines [1,2]. These Th1 and Th2 cells have opposing roles, regulating immune responses to intracellular and extracellular path...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1998
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.188.12.2321